No, anti-wrinkle injections do not hurt. In fact, they can provide many benefits including pain relief, increased collagen production, elasticity and density, and sharper contours. The first step in selecting your anti-wrinkle treatment or wrinkle injection is to weigh the benefits against the potential risks. If you are thinking of having this treatment done, talk it over with your doctor first to make sure it is right for you. It is also a good idea to take pain medication before the injection so that you are not in pain afterwards. Patients who use anti-wrinkle injections tend to see results within about four weeks. The treatments not only smooth out fine lines and wrinkles but also plump up the skin/tighten skin pores making your face look fresh and youthful looking.